Capsules - 1 capsule:
Modified release capsules.
10 capsules in a PVC/PE/PVDC/A1 blister.
3 blisters with instructions for use in a cardboard box.
No. 1 hard gelatin capsules, body: light pinkish yellow, opaque, cap: pinkish brown, opaque. Capsule contents: mixture of white granulate (diclofenac sodium) and pink powder (thiamine hydrochloride, pyridoxine hydrochloride, cyanocobalamin).
Combined analgesic (non-narcotic analgesic + vitamin).
Absorption of diclofenac is fast and complete, food slows down the rate of absorption by 1-4 hours and reduces the maximum concentration by 40%. After oral administration of 50 mg, the maximum concentration (Cmax) - 1.4 μg / ml is reached after 2-3 hours. Plasma concentration is linearly dependent on the size of the administered dose.
Changes in the pharmacokinetics of diclofenac against the background of repeated administration are not observed, do not cumulate.
Bioavailability - 50%. Communication with plasma proteins - more than 99% (most of it binds to albumin). Penetrates into the synovial fluid; the maximum concentration in synovial fluid is observed 2-4 hours later than in plasma. The half-life from the synovial fluid is 3-6 hours (the concentration of the active substance in the synovial fluid 4-6 hours after the administration of the drug is higher than in plasma, and remains higher for another 12 hours). The relationship between the concentration of the drug in the synovial fluid and the clinical efficacy of the drug has not been elucidated. Metabolism: 50% of the active substance is metabolized during the "first pass" through the liver. Metabolism occurs as a result of multiple or single hydroxylation and conjugation with glucuronic acid. The enzyme system P450 CYP2C9 takes part in the metabolism of the drug. The pharmacological activity of metabolites is lower than that of diclofenac.
The systemic clearance is 350 ml/min, the volume of distribution is 550 ml/kg. The plasma half-life is 2 hours. 65% of the administered dose is excreted as metabolites by the kidneys; less than 1% is excreted unchanged, the rest of the dose is excreted as metabolites in the bile. In patients with severe renal insufficiency (creatinine clearance less than 10 ml / min), the excretion of metabolites in the bile increases, while an increase in their concentration in the blood is not observed.
In patients with chronic hepatitis or compensated liver cirrhosis, the pharmacokinetic parameters of diclofenac do not change. Diclofenac passes into breast milk.
The vitamins that make up Neurodiclovit are water-soluble, which excludes the possibility of their accumulation in the body. Thiamine and pyridoxine. absorbed in the upper small intestine, metabolized in the liver and excreted by the kidneys (about 8-10% - unchanged). The degree of absorption depends on the dose, with an overdose, the excretion of thiamine and pyridoxine through the intestine increases significantly. The absorption of cyanocobalamin depends to a large extent on the presence of an internal factor in the body (in the stomach and upper small intestine), further delivery of the vitamin to the tissues is determined by the transport protein transcobalamin. After metabolism in the liver, cyanocobalamin is excreted mainly with bile, the degree of excretion by the kidneys is variable - from 6 to 30%.
Diclofenac has anti-inflammatory, analgesic, antiplatelet and antipyretic effects. Indiscriminately inhibiting cyclooxygenase 1 and 2, disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins in the focus of inflammation.
In rheumatic diseases, the anti-inflammatory and analgesic effect of diclofenac contributes to a significant decrease in the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the joint. With injuries, in the postoperative period, diclofenac reduces pain and inflammatory edema.
Thiamine (vitamin B1) in the human body as a result of phosphorylation processes turns into cocarboxylase, which is a co-enzyme of many enzymatic reactions. Vitamin B1 plays an important role in carbohydrate, protein and fat metabolism. Actively participates in the processes of nerve excitation in synapses.
Pyridoxine (vitamin B6) is necessary for the normal functioning of the central and peripheral nervous system. In the phosphorylated form, it is a coenzyme in the metabolism of amino acids (decarboxylation, transamination, etc.). It acts as a coenzyme for the most important enzymes that act in nerve tissues. Participates in the biosynthesis of many neurotransmitters - such as dopamine, serotonin, norepinephrine, adrenaline, oppression II and gamma-aminobutyric acid (GABA).
Cyanocobalamin (vitamin B12) is necessary for normal hematopoiesis and maturation of red blood cells, and also participates in a number of biochemical reactions that ensure the vital activity of the body - in the transfer of methyl groups, in the synthesis of nucleic acids, proteins, in the metabolism of amino acids, carbohydrates, lipids. It has a beneficial effect on processes in the nervous system (nucleic acid synthesis and lipid composition of cerebrosides and phospholipids). The coenzymatic forms of cyanocobalamin, methylcobalamin and adenosylcobalamin, are essential for cell replication and growth.
The combination of B vitamins potentiates the analgesic effect of diclofenac.
Pain syndrome with inflammation of a non-rheumatic nature:
Inflammatory and degenerative diseases of the joints and spine (chronic polyarthritis, osteoarthritis, spondylarthrosis).
Neuritis and neuralgia (cervical syndrome, lumbago, lumbar ischialgia).
Acute gouty arthritis.
Hypersensitivity to the components of the drug (including other non-steroidal anti-inflammatory drugs or vitamins), erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), bleeding from the gastrointestinal tract, intracranial bleeding, complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid (ASA) or other non-steroidal anti-inflammatory drugs (NSAIDs) (including history), hematopoietic disorders, hemostasis disorders (including hemophilia), inflammatory bowel disease, severe hepatic and heart failure, period after coronary artery bypass grafting, severe renal failure (creatinine clearance less than 30 ml / min), progressive kidney disease, active liver disease, confirmed hyperkalemia, childhood, pregnancy, lactation.
With caution: peptic ulcer of the stomach and duodenum, ulcerative colitis, Crohn's disease, a history of liver disease, hepatic porphyria, chronic liver failure, chronic heart failure, arterial hypertension, a significant decrease in circulating blood volume (including after extensive surgery ), elderly patients (including those receiving diuretics, debilitated patients and those with low body weight), bronchial asthma, simultaneous use of glucocorticosteroids (including prednisalone), anticoagulants (including warfarin), antiplatelet agents ( including ASA, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline), coronary heart disease, cerebrovascular disease, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, chronic smoking renal insufficiency (creatinine clearance 30 - 60 ml / min), the presence of Helicobacter pylori infection, duration use of NSAIDs, alcoholism, severe somatic diseases.
The use of the drug during pregnancy and lactation is contraindicated.
Gastrointestinal tract: more than 1% - epigastric pain, feeling of bloating, diarrhea, nausea, constipation, flatulence, increased activity of aminotransferases, peptic ulcer with possible complications (bleeding, perforation), gastrointestinal bleeding; less than 1% - vomiting, jaundice, melena, blood in the feces, damage to the esophagus, aphthous stomatitis, dry mucous membranes (including the mouth), hepatitis (possibly fulminant), liver necrosis, cirrhosis, hepatorenal syndrome, change in appetite, pancreatitis , cholecystopancreatitis, colitis.
Nervous system: more often than 1% - headache, dizziness; less than 1% - sleep disturbance, drowsiness, depression, irritability, aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases), convulsions, general weakness, disorientation, nightmares, a feeling of fear.
Sense organs: more than 1% - tinnitus; less than 1% - blurred vision, diplopia, taste disturbance, reversible or irreversible hearing loss, scotoma.
Skin: more often 1% - skin itching, skin rash; less often 1% - alopecia, urticaria, eczema, toxic dermatitis, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), increased photosensitivity, punctate hemorrhages, bullous rashes.
Genitourinary system: more often than 1% - fluid retention; less often 1% - nephrotic syndrome, proteinuria, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal failure, azotemia.
Hematopoietic organs and the immune system: less than 1% - anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, worsening of the course of infectious processes (including the development of necrotizing fasciitis).
Respiratory system: less than 1% - cough, bronchospasm, laryngeal edema, pneumonia.
Cardiovascular system: less than 1% - increased blood pressure; heart failure, extrasystole, chest pain, myocardial infarction.
Allergic reactions: less than 1% - anaphylactoid reactions, anaphylactic shock (usually develops rapidly), swelling of the lips and tongue, allergic vasculitis.
The drug increases the plasma concentration of digoxin, methotrexate, lithium preparations and cyclosporine.
Reduces the effect of diuretics, against the background of potassium-sparing diuretics, the risk of hyperkalemia increases; against the background of anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase) - the risk of bleeding (often from the gastrointestinal tract).
Reduces the effects of antihypertensive and hypnotic drugs. Increases the likelihood of side effects of other NSAIDs and glucocorticosteroid drugs (bleeding in the gastrointestinal tract), methotrexate toxicity and cyclosporine nephrotoxicity. Acetylsalicylic acid reduces the concentration of diclofenac in the blood. Simultaneous use with paracetamol increases the risk of developing nephrotoxic effects of diclofenac. Reduces the effect of hypoglycemic agents.
Cefamandol, cefoperazone, cefotetan, valproic acid and plicamycin increase the incidence of developed hypoprothrombinemia.
Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases nephrotoxicity. Simultaneous use with ethanol, colchicine, corticotropin, serotonin reuptake inhibitors and St. John's wort increases the risk of bleeding in the gastrointestinal tract.
Diclofenac enhances the effect of drugs that cause photosensitivity.
Antibacterial drugs from the quinolone group - the risk of developing seizures.
Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity. The drug reduces the antiparkinsonian effectiveness of levodopa. Ethanol sharply reduces the absorption of thiamine (blood levels can decrease by 30%). Long-term treatment with anticonvulsants can lead to thiamine deficiency. The use of colchicine and biguanides reduces the absorption of cyanocobalamin. While taking the drug, it is not recommended to take multivitamin complexes that include vitamins of group B.
Capsules should be taken orally with meals, without chewing and drinking plenty of liquid.
Usually the drug is prescribed 1 capsule 1-3 times a day.
Adults Neurodiclovit is prescribed 1 capsule - at the beginning of treatment 3 times a day, as a maintenance dose - 1-2 times a day. The duration of therapy depends on the nature and severity of the disease.
Symptoms: vomiting, bleeding from the gastrointestinal tract (GIT), epigastric pain, diarrhea, dizziness, tinnitus, lethargy, convulsions; rarely - increased blood pressure, acute renal failure, hepatotoxic effect, respiratory depression, coma.
Treatment: gastric lavage, activated charcoal, symptomatic therapy aimed at eliminating high blood pressure,. renal dysfunction, convulsions, gastrointestinal irritation, respiratory depression. Forced diuresis, hemodialysis are ineffective (due to a significant connection with proteins and intensive metabolism).
During the period of treatment with the drug, systematic monitoring of the picture of peripheral blood, liver and kidney function, and examination of feces for the presence of blood should be carried out.
To reduce the risk of developing adverse effects on the part of the gastrointestinal tract, the minimum effective dose should be used for the lowest possible short course. In order to quickly achieve the desired therapeutic effect, the tablets are taken 30 minutes before a meal. In other cases, take before, during or after a meal, without chewing, drinking plenty of water. Due to the important role of prostaglandins in maintaining renal blood flow, special care should be taken when prescribing to patients with heart or kidney failure, as well as in the treatment of elderly patients taking diuretics and patients who, for any reason, have a decrease in circulating blood volume (in including after extensive surgery). If, in such cases, diclofenac is prescribed, it is recommended to monitor renal function as a precautionary measure. If, while taking the drug, an increase in the activity of "liver" transaminases persists or increases, if there are clinical symptoms of hepatotoxicity (including nausea, fatigue, drowsiness, diarrhea, pruritus, jaundice), treatment should be discontinued. Diclofenac (like other NSAIDs) can cause hyperkalemia. Due to the negative effect on fertility, the drug is not recommended for women planning to become pregnant. In patients with infertility (including those undergoing examination), it is recommended to discontinue the drug.
Influence on the ability to drive vehicles and control mechanisms
During the period of treatment, a decrease in the speed of mental and motor reactions is possible, therefore, it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Neurodiclovit and its analogues quickly and effectively eliminate pain in diseases of the musculoskeletal system. Neurodiclovit is a combination drug from the Austrian company Gerot Lannach Pharma. The drug consists of diclofenac sodium and B vitamins.
For example, with osteochondrosis of the spine, which affects more than half of humanity, there may be a sharp pain in the back. Because of it, a person literally freezes in one position, since an attempt to make any movement will only increase the pain. This condition is the result of compression of the spinal nerves. This is the result of degenerative cartilage damage and reactive changes occurring in the vertebrae.
Neurodiclovit is convenient to use, as it saves the patient from taking a number of drugs and reduces the duration of treatment. The results of studies have shown that when using vitamins B with diclofenac, the pain goes away faster. And since diclofenac has many side effects, it is preferable to take a shorter course of treatment with this medicine. In this case, this drug is the most suitable remedy that copes with disorders of the musculoskeletal system and the nervous system.
Diseases for which this drug is indicated:
The drug is also used with an increase in temperature, the formation of edema and swelling.
Each capsule contains:
There are no analogues, which would simultaneously include vitamins of group B and NSAIDs. Therefore, if necessary, the most suitable substitutes are selected.
Similar drugs, the trade names of which sound different, but their main substance is the same, with which Neurodiclovit can be replaced:
In various preparations, the dose of diclofenac is different, therefore, when selecting an analogue, this fact must be taken into account. Since each drug has its own specifics and contraindications, a doctor's consultation is required.
Treatment with Neurodiclovitis is often continued with Neuromultivit. This drug contains similar vitamins, but without diclofenac. Neuromultivit is prescribed for the treatment of neurological diseases. When the question arises of replacing Neurodiclovit, the fact of the presence of neuritis is taken into account. If such therapy is necessary, Neuromultivit can be used instead of Neurodiclovit.
In complex treatment, these vitamins enhance the properties of diclofenac. Due to this, this combination of drugs quickly relieves pain of a neuralgic nature.
Also indications for use are:
All nonsteroidal drugs have side effects, and diclofenac is no exception.
Digestive system:
From the side of the nervous system, the following side effects are possible:
Sense organs:
Urogenital system:
Complications from chronic diseases are possible.
Respiratory system:
Often, when doctors prescribe medications to a patient, the question arises of replacing drugs with more affordable ones. Many people think that Russian analogues are cheaper because they are not subject to additional import duties.
The price of similar drugs manufactured by different companies can differ tenfold. And the buyer has a natural question, if the active substance is the same, then why such a difference in cost.
The manufacturer spends a lot of money on the original drug - research, advertising, etc. Therefore, the manufacturer tries to compensate for the losses by selling the drug at a high price. And generics are no longer being researched and produced using the same technology, but under a different name.
The next aspect that significantly increases the price is the packaging. The more beautiful and better it is, the higher the price. But this does not affect the quality of the medicine. As for the choice between a domestic product and an imported one, it is known that foreign analogues are produced using higher technologies, therefore the quality of such drugs is much higher.
In this article, you can read the instructions for using the drug Neurodiclovitis. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Neurodiclovit in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Neurodiclovit analogues in the presence of existing structural analogues. Use for the treatment of pain and inflammation in arthritis, arthrosis, sciatica, lumbago in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.
Neurodiclovitis- non-steroidal anti-inflammatory drug (NSAID) in combination with B vitamins. Diclofenac has anti-inflammatory, analgesic, antiplatelet and antipyretic effects. Indiscriminately inhibiting COX-1 and COX-2, disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins in the focus of inflammation. In rheumatic diseases, the anti-inflammatory and analgesic effect of diclofenac contributes to a significant decrease in the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the joint. With injuries, in the postoperative period, diclofenac reduces pain and inflammatory edema.
Thiamine (vitamin B1) in the human body as a result of phosphorylation processes turns into cocarboxylase, which is the coenzyme of many enzymatic reactions. Vitamin B1 plays an important role in carbohydrate, protein and fat metabolism. Actively participates in the processes of nerve excitation in synapses.
Pyridoxine (vitamin B6) is necessary for the normal functioning of the central and peripheral nervous system. In the phosphorylated form, it is a coenzyme in the metabolism of amino acids (decarboxylation, transamination). It acts as a coenzyme for the most important enzymes that act in nerve tissues. Participates in the biosynthesis of many neurotransmitters - such as dopamine, serotonin, norepinephrine, epinephrine, histamine and GABA.
Cyanocobalamin (vitamin B12) is necessary for normal hematopoiesis and maturation of red blood cells, and also participates in a number of biochemical reactions that ensure the vital activity of the body - in the transfer of methyl groups, in the synthesis of nucleic acids, protein, in the metabolism of amino acids, carbohydrates, lipids. It has a beneficial effect on processes in the nervous system (nucleic acid synthesis and lipid composition of cerebrosides and phospholipids). The coenzymatic forms of cyanocobalamin, methylcobalamin and adenosylcobalamin, are essential for cell replication and growth.
The combination of B vitamins potentiates the analgesic effect of diclofenac.
Compound
Diclofenac sodium + Thiamine hydrochloride (vitamin B1) + Pyridoxine hydrochloride (vitamin B6) + Cyanocobalamin (vitamin B12) + excipients.
Pharmacokinetics
Diclofenac
Absorption of diclofenac is fast and complete. Food slows down the rate of absorption by 1-4 hours and reduces Cmax by 40%. Plasma concentration is linearly related to the dose taken. Bioavailability - 50%. Changes in the pharmacokinetics of diclofenac against the background of repeated administration are not observed, do not cumulate. Plasma protein binding - more than 99% (most associated with albumin). Penetrates into the synovial fluid. Diclofenac is excreted in breast milk. 50% of the active substance is metabolized during the "first pass" through the liver. Metabolism occurs as a result of multiple or single hydroxylation and conjugation with glucuronic acid. The CYP2C9 isoenzyme takes part in the metabolism of the drug. The pharmacological activity of metabolites is lower than that of diclofenac. The concentration of diclofenac in the synovial fluid 4-6 hours after taking the drug is greater than in plasma, and remains higher than the plasma values for another 12 hours. The relationship between the concentration of the drug in the synovial fluid and the clinical efficacy of the drug has not been elucidated. 65% of the administered dose is excreted as metabolites by the kidneys, less than 1% is excreted unchanged, the rest of the dose is excreted as metabolites in the bile.
Vitamins B1, B6, B12
The vitamins that make up Neurodiclovit are water-soluble, which excludes the possibility of their accumulation in the body.
Thiamine and pyridoxine are absorbed in the upper small intestine, metabolized in the liver and excreted by the kidneys (about 8-10% unchanged). The degree of absorption depends on the dose, with an overdose, the excretion of thiamine and pyridoxine through the intestine increases significantly.
The absorption of cyanocobalamin depends to a large extent on the presence of an internal factor in the body (in the stomach and upper small intestine), further delivery of the vitamin to the tissues is determined by the transport protein transcobalamin. After metabolism in the liver, cyanocobalamin is excreted mainly with bile, the degree of excretion by the kidneys is variable - from 6 to 30%.
Indications
Release forms
Retard modified-release capsules (sometimes erroneously called tablets).
Other dosage forms, whether injections in injection ampoules, ointment, cream or gel, did not exist at the time of publication of the drug in the Directory.
Instructions for use and dosage
Capsules should be taken orally with meals, without chewing and with plenty of liquid.
Usually prescribed 1 capsule 1-3 times a day.
Neurodiclovit adults are prescribed 1 capsule: at the beginning of treatment - 3 times a day, as a maintenance dose - 1-2 times a day. The duration of therapy depends on the nature and severity of the disease.
Side effect
Contraindications
With caution: peptic ulcer of the stomach and duodenum, ulcerative colitis, Crohn's disease, a history of liver disease, hepatic porphyria, chronic liver failure, chronic heart failure, arterial hypertension, a significant decrease in BCC (including after extensive surgery), elderly patients (including those receiving diuretics, debilitated patients and those with low body weight), bronchial asthma, simultaneous use of glucocorticosteroids (GCS) (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline), ischemic heart disease, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, chronic renal insufficiency (CC 30-60 ml / min), the presence of Helicobacter pylori infection, long-term use of NSAIDs, alcoholysis m, severe somatic diseases, smoking.
Use during pregnancy and lactation
The drug Neurodiclovit is contraindicated during pregnancy and lactation (breastfeeding).
Due to the negative effect on fertility, it is not recommended to prescribe the drug to women planning to become pregnant.
In patients with infertility (including those undergoing examination), it is recommended to discontinue the drug.
Use in children
Contraindicated in childhood.
Use in elderly patients
With caution, the drug should be prescribed to elderly patients.
special instructions
During the period of treatment with the drug, systematic monitoring of the picture of peripheral blood, liver and kidney function, and examination of feces for the presence of blood should be carried out.
To reduce the risk of adverse events in the gastrointestinal tract, Neurodiclovit should be used at the lowest effective dose for the shortest possible course.
In order to quickly achieve the desired therapeutic effect, the tablets are taken 30 minutes before a meal. In other cases, take before, during or after a meal, without chewing, drinking plenty of water.
Due to the important role of prostaglandins in maintaining renal blood flow, special care should be taken when prescribing to patients with heart or renal insufficiency, as well as in the treatment of elderly patients receiving diuretics and patients who, for any reason, have a decrease in BCC (including hours after extensive surgery). If diclofenac is prescribed in such cases, it is recommended to monitor renal function as a precautionary measure.
If, while taking the drug, an increase in liver transaminase activity persists or increases, if clinical symptoms of hepatotoxicity (including nausea, fatigue, drowsiness, diarrhea, pruritus, jaundice) are noted, treatment should be discontinued.
Diclofenac (like other NSAIDs) can cause hyperkalemia.
Influence on the ability to drive vehicles and control mechanisms
During the period of treatment, a decrease in the speed of mental and motor reactions is possible, so patients should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.
drug interaction
With the simultaneous use of Neurodiclovit increases the plasma concentration of digoxin, methotrexate, lithium preparations and cyclosporine.
With the simultaneous use of Neurodiclovit reduces the effect of diuretics, against the background of potassium-sparing diuretics, the risk of hyperkalemia increases.
With the simultaneous use of Neurodiclovit and anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase), the risk of bleeding (often gastrointestinal bleeding) increases.
With the simultaneous use of Neurodiclovit reduces the effects of antihypertensive and hypnotic drugs.
With the simultaneous use of Neurodiclovit increases the likelihood of side effects of other NSAIDs and corticosteroids (gastrointestinal bleeding), methotrexate toxicity and cyclosporine nephrotoxicity.
Acetylsalicylic acid (Aspirin) reduces the concentration of diclofenac in the blood.
The simultaneous use of Neurodiclovit with paracetamol increases the risk of developing nephrotoxic effects of diclofenac.
With the simultaneous use of Neurodiclovit reduces the effect of hypoglycemic agents.
With simultaneous use with Neurodiclovit, cefamandol, cefoperazone, cefotetan, valproic acid and plicamycin increase the incidence of hypoprothrombinemia.
Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases the risk of nephrotoxicity.
The simultaneous appointment of Neurodiclovit with ethanol (alcohol), colchicine, corticotropin, serotonin reuptake inhibitors and St. John's wort increases the risk of gastrointestinal bleeding.
Diclofenac enhances the effect of drugs that cause photosensitivity.
Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity.
Neurodiclovit reduces the antiparkinsonian efficacy of levodopa.
Ethanol (alcohol) dramatically reduces the absorption of thiamine (blood levels can drop by 30%).
Long-term treatment with anticonvulsants can lead to thiamine deficiency.
The use of colchicine and biguanides reduces the absorption of cyanocobalamin.
Analogues of the drug Neurodiclovit
Neurodiclovit has no structural analogues for the active substance. The combination of active ingredients in the composition of the drug is unique and has no analogues.
Analogues for the therapeutic effect (drugs for the treatment of sciatica):
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.
Neurodiclovit is used to relieve pain in various clinical disciplines. In the pharmacy network, you can buy Neurodiclovit analogues, the main component of which is diclofenac. However, they do not belong to exact substitutes, since they do not contain B vitamins.
Neurodiclovit is non-steroidal anti-inflammatory means . Most often prescribed for neurological diseases and diseases of the joints.
AT combined the composition of the drug includes diclofenac sodium and water soluble group B vitamins: 1, 6, 12, which enhance the effect of the main active ingredient. Thus , a significantly lower dosage is required for therapy .
When taking the drug, side effects are often observed. Most often from the side digestive systems .
The vitamin component of the drug significantly softens the aggressive effect of the drug on the gastric mucosa. This is the main advantage of Neurodiclovit compared to its substitutes.
All products on the list contain diclofenac - the main active ingredient of the drug Neurodiclovit.
1. Ortofen (Russia). The drug is used in symptomatic pain relief therapy.
This analogue of the drug Neurodiclovit has proven itself in the treatment of pathologies musculoskeletal apparatus.
Has a pronounced anti-inflammatory and analgesic activity .
Ortofen is often prescribed in combination with other medicines in the treatment degenerative-dystrophic joint diseases and soft tissue injuries.
Prevents the development of acute inflammatory processes in the muscles.
2. Diclofenac (Serbia). A proven tool with a large evidence base. It has prolonged action . Stops development inflammatory process . It has a pronounced analgesic effect.
Indicated for the relief of acute neuropathic pain.
Effective for arthritis of any etiology.
It is successfully used in the treatment of ENT diseases.
It is an "ambulance" in traumatology.
Another indisputable plus is that this analogue is several times cheaper than Neurodiclovit.
3. Diklak (Switzerland). Designed to eliminate neurological, rheumatic , traumatological, muscle pain .
An effective remedy in cases of exacerbations of osteochondrosis, periarthritis, osteoarthritis, myalgia.
Relieves pain after surgery.
This analogue of Neurodiclovit in tablets is successfully used in sports medicine.
4. Voltaren (Switzerland). OTC medicine prolonged actions . It is prescribed in many clinical disciplines for the rapid relief of acute pain.
Gives a stable analgesic effect in the treatment of diseases of the musculoskeletal system of various origins.
Removes inflammatory edema.
Normalizes the condition of the joints.
Also, this substitute Neurodiclovit is used in gynecology and ENT practice.
5. Naklofen Duo (Russia). The drug of choice for the relief of pain. Eliminates acute muscular , articular inflammations .
It is prescribed for acute radicular syndromes, arthritis, synovitis.
Application at the initial stage of exacerbation reduces the process of inflammation.
The analogue in capsules Neurodiclovit is effective as part of complex measures in the treatment of inflammatory diseases of the pelvic organs.
Pain in the back and joints can knock out of the usual rhythm of life for a long time, so everyone who suffers from osteochondrosis, sciatica, arthritis should have a good painkiller in the first aid kit. And for many, the salvation from pain is Neurodiclovit, whose analogues are produced by Russian, Ukrainian, Belarusian and many other pharmaceutical companies.
The drug has a powerful anti-inflammatory and analgesic effect, this effect is provided by the well-thought-out composition of Neurodiclovit.
Due to the complex composition of Neurodiclovit tablets, they have a complex effect on the body. To explain the mechanism of the drug, one should understand the causes of pain in diseases of the joints, spine, and injuries.
With osteochondrosis, other pathologies of the spinal column, pain occurs due to compression of the nerve roots by the vertebrae. Local inflammation is also formed, as a reaction to injury, swelling appears - this increases pain.
According to the same principle, there are pains in the joints with arthritis, arthrosis, in the muscles with trauma, and so on. Accordingly, to eliminate discomfort, it is necessary to eliminate inflammation. Non-steroidal drugs, to which Diclofenac belongs, cope with this.
For the speedy recovery of damaged nerve endings, Neurodiclovit contains B vitamins. Due to these substances, the general condition of the nervous system improves, and at high dosages they also have an analgesic effect, enhance the analgesic effect of NSAIDs.
Thus, the combination of B vitamins and diclofenac is optimal for various pathologies of the bone and muscle system. This combination has proven its effectiveness in diseases of the nervous system. So, in the course of studies it was found that Neurodiclovit is more effective in neuritis and neuralgia than NSAID monotherapy. It was also found that the use of vitamins can reduce the daily dosage of the anti-inflammatory drug, respectively, reduce the number of side effects, improve the tolerability of treatment.
The described medicine in the form of capsules is produced by the Austrian company Gerot Lannach Pharma. Accordingly, its cost in pharmacies is higher than that of domestically produced drugs. But you can find analogues of Neurodiclovit - products with the same active ingredient in the composition.
To date, drugs with the same composition, 100% compliance, are not produced. But there are many drugs, the active substance of which are known to many NSAIDs. Among the most popular is Diclofenac. The drug is produced in different dosage forms, tablets, capsules, suppositories, ointments are available.
Ibuprofen and medicines based on it have a similar effect. This substance also belongs to NSAIDs, has the same effect, therapy is easily tolerated by them, so Ibuprofen can be recommended as a replacement for Neurodiclovit.
In addition to Ibuprofen, you can take Ketorolac, also made in Russia. This powerful NSAID, acts faster and stronger than Diclofenac, Ibuprofen, can be used not only for neurological pain, but also in dental practice.
In Ukraine, an analogue of the drug Neurodiclovit is also produced, but the composition of the drug differs from the original.
All tablets can be easily purchased at the pharmacy without a prescription. When treating, it is important to follow the manufacturer's instructions to prevent overdose or unwanted interactions with other drugs.
Few drugs with a similar effect are produced in Belarus, but in pharmacies you can buy an inexpensive analogue of Neurodiclovit. These are Diclofenac-LF, Ibuprofen, Dex (dexketoprofen), Ketonof-LF (ketorolac), Nimelide-LF (nimesulide) and so on. All drugs in their composition contain different versions of non-steroidal anti-inflammatory drugs with a similar mechanism of action and effectiveness.
The use of these drugs will give the same effect as taking Neurodiclovit. They well anesthetize, relieve inflammation, are quite easily tolerated by the body - subject to dosages and treatment regimens.
If you look for analogues cheaper, produced by foreign companies, the choice is large. At the heart of foreign analogues are the same NSAIDs. That is, diclofenac, ibuprofen, ketorolac, ketoprofen, nimesulide, paracetamol.
Imported drugs have the same indications and contraindications as Neurodiclovit, they have the same effect - anti-inflammatory, analgesic. Therefore, they can be purchased, used for neuralgia, neuritis, arthritis, osteochondrosis, radiculitis, and various injuries.
Foreign pharmaceutical companies also produce other drugs based on non-steroidal anti-inflammatory drugs. The range is quite wide, as well as the price range.
When choosing such drugs, you need to consider that they can match the original only in terms of the content of one component - diclofenac or another NSAID. But there are no B vitamins in the analogues. This means that in order to obtain the same effect, it is necessary to additionally take vitamins - individually or by buying complexes. There are many such complexes: Neurovitan, Beforten, Neurobex Neo, Bekovit and so on.
But the best solution would be to consult the attending physician - a neurologist, therapist, orthopedist or rheumatologist will be able to choose the optimal combination of drugs so that they have the desired effect and do not cause drug overload in the body.
Self-medication in such cases is unacceptable, as in all others.
It is also important to take into account all contraindications, special instructions for use. Particular attention is paid to chronic diseases, childhood, pregnancy, breastfeeding, severe disorders of the liver and kidneys. Therefore, in case of any pathologies, it is strictly forbidden to independently prescribe treatment for yourself - consultation with a specialist is required.
