Captopril is a drug used by patients with high blood pressure. It can be prescribed in combination with other medicines. Sometimes Captopril STI is included in the course of treatment for patients after a heart attack.
This drug can be taken by patients with high sugar levels, this applies to type 1 diabetes. Analogs can be used as directed by a doctor. But Captopril STI is an inexpensive remedy from the entire list of similar drugs. It comes in capsule and tablet form.
Captopril STI, its instructions for use are attached to the drug itself. Captopril helps to dilate the arteries, resulting in a decrease in pressure. It helps the heart work better. This reaction occurs regardless of the hormonal background. Improves blood circulation in the vessels of the myocardium and kidneys.
Long-term use can improve the condition of blood vessels and heart muscle. He will also control the process of platelet unification, and this will lead to stabilization of the condition of patients with acute heart failure.
Captopril helps to normalize kidney function and alleviate the condition of patients diagnosed with diabetes mellitus. The healing effect will come in about an hour. The duration of treatment is 2 or 3 weeks.
How does the drug work in the body?
After 3 hours, the drug will begin to be excreted from the body. If the patient's kidneys are not working properly, this period can increase to 32 hours. Most of the medication will pass in the urine, and the rest through the cells.
The drug is used for adult patients according to a certain scheme:But, if a person does not feel a decrease in blood pressure, the dose can be increased to 4 tablets at a time. But such changes in the course of treatment can only be made by a doctor. The largest dose per day should not exceed 150 milligrams. If this happens, side effects may occur.
Doctors prescribe this drug after a heart attack after a few days, but provided that the patient's condition has stabilized, the dose will gradually increase. It is set individually, taking into account the general condition of the patient.
If the medicine is used incorrectly, the patient may experience side effects.
If any of these signs appear, you must stop taking Captopril STI and consult a doctor.
These include:If Captopril is used as directed by a physician, in compliance with the dosage, any side effects can be avoided.
In case of an overdose, the patient begins to experience:
In this case, an urgent withdrawal of the drug is required and therapy is required, which will allow to remove its remnants from the body. In some cases, it may be necessary to use an artificial kidney.
The appointment of Captopril is done after examining the patient. It is necessary to restore the right amount of fluid and salt in the body. It must be used very carefully by patients with any impairment in the functioning of the kidneys.
During the examination, it is necessary to identify the level of potassium in the body, since this medicine will increase it. A separate approach is selected for patients with skin diseases. It is best to avoid driving while using Captopril.
Combining medication with other drugs:Medications for the treatment of high blood pressure should only be taken as directed by a doctor.
In this case, the dosage must be strictly observed.
If a person begins to feel worse or side effects appear, the medication is stopped and a specialist consultation is required.
Captopril STI is an affordable and effective drug for the treatment of complex diseases. It helps to undergo rehabilitation after a heart attack and normalizes the work of the vascular system.
Dosage Form: & nbsp tablets Composition:1 tablet contains:
active substance: captopril 25 mg or 50 mg;
Excipients: microcrystalline cellulose, milk sugar, corn starch, aerosil, magnesium stearate.
Description:Tablets are white or white with a creamy shade of color with a characteristic odor, biconvex with a risk on one side. Light marbling is allowed. In appearance, they must meet the requirements of GF XI, no. 2, p. 154.
Pharmacotherapeutic group: ACE inhibitor ATC: & nbspC.09.A.A.01 Captopril
Pharmacodynamics:Angiotensin-converting enzyme (ACE) inhibitor. Reduces the formation of angiotensin II from angiotensin I. A decrease in the content of angiotensin II leads to a direct decrease in the release of aldosterone. At the same time, the total peripheral vascular resistance, blood pressure, fasting and preload on the heart are reduced. Expands arteries more than veins. It causes a decrease in the degradation of bradykinin (one of the effects of ACE) and an increase in prostaglandin synthesis. The antihypertensive effect does not depend on the activity of plasma renin, a decrease in blood pressure is noted with a normal or even reduced level of the hormone, which is due to the effect on tissue renin-angiotensin systems. Strengthens coronary and renal blood flow. With prolonged use, it reduces the severity of hypertrophy of the myocardium and the walls of resistive arteries. Improves blood supply to the ischemic myocardium. Reduces platelet aggregation. Helps reduce content Na + in patients with heart failure. A decrease in blood pressure, in contrast to direct vasodilators (hydralazine, minoxidil, etc.), is not accompanied by reflex tachycardia and leads to a decrease in myocardial oxygen demand. With heart failure, an adequate dose does not affect the value of blood pressure. The maximum decrease in blood pressure after oral administration is observed after 60-90 minutes. The duration of the hypotensive effect is dose-dependent and reaches optimal values within a few weeks. Pharmacokinetics:Absorption is fast, reaching 75% (food intake reduces absorption by 30-40%). Bioavailability - 35-40% (the effect of "first pass" through the liver). The connection with blood plasma proteins (mainly with albumin) is 25-30%. The maximum concentration in blood plasma (114 ng / ml) with oral administration is reached after 30-90 minutes. It penetrates the blood-brain barrier and the placental barrier poorly (less than 1%). It is metabolized in the liver to form the disulfide dimer of captopril and captopril-cysteindisulfide. The metabolites are pharmacologically inactive.
The half-life is 3 hours. Excreted by the kidneys 95% (40-50% unchanged, the rest in the form of metabolites). It is secreted with breast milk. 4 hours after a single ingestion in the urine contains 38% of unchanged captopril and 28% in the form of metabolites, after 6 hours - only in the form of metabolites; in daily urine - 38% of unchanged captopril and 62% - in the form of metabolites. The half-life for impaired renal function is 3.5-32 hours. Cumulates in chronic renal failure.
Indications:Arterial hypertension, including renovascular; chronic heart failure (as part of complex therapy); dysfunction of the left ventricle after myocardial infarction in a clinically stable condition; diabetic nephropathy against the background of type I diabetes mellitus (with albuminuria more than 30 mg / day).
Contraindications:Hypersensitivity to the drug and other ACE inhibitors, angioedema (against the background of the use of ACE inhibitors, including a history); severe renal or liver dysfunction; hyperkalemia; bilateral stenosis of the renal arteries or stenosis of an artery of a solitary kidney with progressive azotemia; condition after kidney transplantation; aortic stenosis and similar obstructive changes that impede the outflow of blood; pregnancy, lactation period; age up to 18 years.
Carefully:Severe autoimmune diseases (especially SLE or scleroderma), inhibition of bone marrow hematopoiesis (risk of neutropenia and agranulocytosis), cerebral ischemia, diabetes mellitus (increased risk of hyperkalemia); patients on hemodialysis; diet with limited sodium; primary hyperaldosteronism; cardiac ischemia; conditions accompanied by a decrease in the volume of circulating blood (including diarrhea, vomiting); elderly age.
Method of administration and dosage:Captopril-STI is prescribed orally 1 hour before meals. The dosage regimen is set individually.
With arterial hypertension, treatment is prescribed with the lowest effective dose of 12.5 mg 2 times a day (rarely from 6.25 mg 2 times a day). Attention should be paid to the tolerance of the first dose within the first hour. If at the same time arterial hypotension develops, the patient must be transferred to a horizontal position (such a reaction to the first dose should not serve as an obstacle to further therapy). If necessary, the dose is gradually increased (with an interval of 2-4 weeks) until the optimal effect is achieved. For mild to moderate arterial hypertension, the usual maintenance dose is 25 mg 2 times a day; the maximum dose is 50 mg 3 times a day. The maximum daily dose is 150 mg.
In elderly patients, the initial dose is 6.25 mg 2 times a day.In case of heart failure, it is prescribed together with diuretics and / or in combination with digitalis drugs (in order to avoid an initial excessive decrease in blood pressure, before the appointment of Captopril-STI, the diuretic is canceled or the dose is reduced). The initial dose is 6.25 mg or 12.5 mg 3 times a day, if necessary, the dose is increased to 25 mg 3 times a day. The maximum daily dose is 150 mg.
In case of impaired left ventricular function after myocardial infarction in clinically stable patients, the use of Captopril-STI can be started as early as 3 days after myocardial infarction. The initial dose is 6.25 mg / day, then the daily dose can be increased to 37.5 - 75 mg in 2-3 doses (depending on the tolerability of the drug). If necessary, the dose is gradually increased to a maximum daily dose of 150 mg / day.
With the development of arterial hypotension, a dose reduction may be required.
Subsequent attempts to use a maximum daily dose of 150 mg should be based on patient tolerance to Captopril-STI.
In diabetic nephropathy, Captopril-STI is prescribed in a daily dose of 75-100 mg / day for 2-3 doses. In insulin-dependent diabetes with microalbuminuria (release of albumin 30-300 mg per day), the dose of the drug is 50 mg 2 times a day. With a total protein clearance of more than 500 mg per day, the drug is effective at a dose of 25 mg 3 times a day.
With a moderate degree of renal dysfunction (CC - not less than 30 ml / min / 1.73 m2), Captopril-STI can be prescribed at a dose of 75-100 mg / day. With a more pronounced degree of renal dysfunction (CC - less than 30 ml / min / 1.73 sq. M), the initial dose should be no more than 12.5 mg / day; in the future, if necessary, the dose of Captopril-STI is gradually increased at rather long intervals, but a lower daily dose of the drug is used than in the case of treatment of arterial hypertension.
If necessary, additional loop diuretics are prescribed, rather than thiazide diuretics.
Side effects:On the part of the cardiovascular system: tachycardia, decreased blood pressure, orthostatic hypotension, peripheral edema.
From the nervous system: dizziness, headache, fatigue, asthenia, paresthesia.
From the respiratory system: dry cough, pulmonary edema, bronchospasm.
From the urinary system: proteinuria, deterioration of renal function (increased levels of urea and creatinine in the blood).
On the part of water-electrolyte metabolism: hyperkalemia, hyponatremia (most often with a salt-free diet and concomitant use of diuretics), proteinuria, increased blood urea nitrogen and creatinine, acidosis.
From the digestive system: decreased appetite, impaired taste, dry mouth, stomatitis, nausea, abdominal pain, dyspeptic symptoms, constipation or diarrhea, increased activity of "liver" transaminases, hyperbilirubinemia, signs of hepatocellular damage (hepatitis) and cholestasis (in rare cases); pancreatitis (in isolated cases).
On the part of the hematopoietic organs: neutropenia, anemia, thrombocytopenia, agranulocytosis.
Allergic reactions: skin rash (maculopapular, less often vesicular or bullous), itching, angioedema, "hot flashes" of blood to the skin of the face, fever, photosensitivity, serum sickness, lymphadenopathy, in rare cases - the appearance of anti-nuclear antibodies in the blood.
Other: general weakness.
Overdose:Symptoms: a pronounced decrease in blood pressure up to collapse, myocardial infarction, acute cerebrovascular accident, thromboembolic complications.
Treatment: to lay the patient with raised lower limbs; take measures aimed at restoring blood pressure (increasing the volume of circulating blood, including intravenous infusion of saline), symptomatic therapy.
The use of hemodialysis is possible; peritoneal dialysis is not effective.
Interaction:Captopril increases the concentration of digoxin in the blood plasma by 15-20%.
Increases the bioavailability of propranolol.
Cimetidine, slowing down the metabolism in the liver, increases the concentration of captopril in the blood plasma.
The antihypertensive effect is weakened by non-steroidal anti-inflammatory drugs (Na + delay and decreased prostaglandin synthesis).
The combination with thiazide diuretics, vasodilators (), verapamil, beta-blockers, tricyclic antidepressants, ethanol, enhances the hypotensive effect.
Combined use with potassium-sparing diuretics, potassium preparations, cyclosporine, potassium supplements, salt substitutes (contain significant amounts of K +) increases the risk of hyperkalemia.
Slows down the elimination of lithium preparations.
When combined with procainamide, allopurinol, flecainide, the risk of developing an immunosuppressive effect increases.
Probenecid slows down the excretion of captopril in the urine.
Clonidine reduces the severity of the hypotensive effect.
Immunosuppressants (or) increase the risk of developing hematological disorders.
Special instructions:Renal function should be monitored before starting, as well as regularly during treatment with Captopril-STI. In patients with chronic heart failure, it is used under close medical supervision.
Against the background of long-term use of Captopril-STI, approximately 20% of patients have an increase in serum urea and creatinine by more than 20%, compared with the normal or baseline value. Less than 5% of patients, especially with severe nephropathies, require discontinuation of treatment due to an increase in creatinine concentration.
In patients with arterial hypertension, when using Captopril-STI, severe arterial hypotension is observed only in rare cases. The likelihood of developing arterial hypotension increases with a deficiency of fluid and salts (for example, after intensive treatment with diuretics), in patients with heart failure or on dialysis.
The possibility of a sharp decrease in blood pressure can be minimized by prior cancellation (4-7 days) of the diuretic or an increase in sodium chloride intake (about a week before the start of admission), or by prescribing Captopril-STI at the beginning of treatment in low doses (6 , 25-12.5 mg / day).
In the first 3 months of therapy, the number of blood leukocytes is monitored monthly, then - once every 3 months; in patients with autoimmune diseases in the first 3 months - every 2 weeks, then every 2 months. If the number of leukocytes is below 4000 / μl, a general blood test is shown, below 1000 / μl - the drug is stopped.
In some cases, against the background of the use of ACE inhibitors, incl. Captopril-STI, an increase in serum K + concentration is observed. The risk of developing hyperkalemia with captopril is increased in patients with renal failure and diabetes mellitus, as well as taking potassium-sparing diuretics, potassium supplements, or other drugs that increase the concentration of K + in the blood (for example, heparin). The simultaneous use of potassium-sparing diuretics and potassium preparations should be avoided.
When carrying out hemodialysis in patients receiving Captopril-STI, the use of dialysis membranes with high permeability (for example, AN 69) should be avoided, since in such cases the risk of developing anaphylactoid reactions increases. In case of development of angioedema, the drug is canceled and careful medical supervision and symptomatic therapy are carried out.
When taking Captopril-STI, a false-positive reaction may occur when urine is analyzed for acetone.
It is prescribed with caution to patients on a low-salt or salt-free diet (increased risk of arterial hypotension).
Impact on the ability to drive vehicles. Wed and fur .:During the period of treatment, one should refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration of attention and work of psychomotor reactions, because dizziness is possible, especially after taking the initial dose. Release form / dosage:Tablets of 25 and 50 mg.
Package:There are 10 tablets in a blister strip or 20, 30, 40, 50 or 60 tablets in a polymer can or a polymer bottle.
For 2, 3, 4, 5 or 6 blisters or a jar, or a bottle, together with instructions for use, are placed in a cardboard box.
Storage conditions:In a dry, dark place at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life:Do not use after the expiration date printed on the package.
Conditions for dispensing from pharmacies: On prescription Registration number: R N002904 / 01 Registration date: 14.01.2009 / 24.06.2010 Expiration date: Perpetual InstructionsIn this medical article, you can read the drug Captopril. The instructions for use will explain at what pressure the pills can be taken, from which the medicine helps, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.
In the article, doctors and consumers can leave only real reviews about Captopril, from which it is possible to find out whether the medicine has helped in the treatment of arterial hypertension and pressure reduction in adults and children, for which it is also prescribed. The instructions list the analogues of Captopril, the prices of the drug in pharmacies, as well as its use during pregnancy.
The drug of the group of ACE inhibitors with hypotensive action is Captopril. Instructions for use recommend taking (12.5 mg, 25 mg and 50 mg tablets for the treatment of arterial hypertension, chronic heart failure.
The dosage form of the drug is tablets. The active substance is captopril, in 1 tablet its content reaches - 12.5; 25 or 50 mg.
The antihypertensive effect of the drug is based on competitive inhibition of ACE activity, as a result of which the rate of conversion of angiotensin I to angiotensin II decreases and its vasoconstrictor effect is eliminated.
Due to the vasodilating action of Captopril, the total peripheral vascular resistance, the wedge pressure in the pulmonary capillaries, and the resistance in the pulmonary vessels are reduced. Exercise tolerance and cardiac output also increase.
With prolonged use, Captopril provides a decrease in the severity of hypertrophy of the myocardium and arterial walls. The drug improves blood supply to the myocardium affected by ischemic disease and reduces platelet aggregation.
Indications for use of the medication include:
Captopril tablets are taken orally 1 hour before meals. The doctor prescribes the daily dose individually based on clinical indications.
The recommended dosage regimen for chronic heart failure (with combination therapy), in the absence of an adequate effect from the use of diuretics: an initial dose of 6.25 mg 2-3 times a day.
The dose is adjusted to an average maintenance dose - 25 mg 2-3 times a day, gradually, with an interval of 2 or more weeks. If it is necessary to further increase the dose, the increase is made once every 2 weeks.
The recommended dosage regimen of Captopril for blood pressure in hypertension: an initial dose of 25 mg 2 times a day. If the therapeutic effect is insufficient, it is recommended to increase the dose gradually, once every 2-4 weeks.
The maintenance dose for moderate forms of arterial hypertension is 25 mg 2 times a day, but not more than 50 mg; for severe forms - 50 mg 3 times a day. The maximum daily dose is 150 mg. 
The daily dosage of the drug for patients with impaired renal function is recommended to be prescribed: with a moderate degree (creatinine clearance (CC) not less than 30 ml / min / 1.73 m2) - 75-100 mg, with a pronounced violation (CC below 30 ml / min / 1.73 m2) - an initial dose of 12.5-25 mg per day.
If necessary, an increase is made for a long time, but the drug is always used in a daily dose less than the usual one.
For elderly patients, the dose is selected strictly individually; it is recommended to start treatment with 6.25 mg 2 times a day and try to maintain the dose at this level. If additional intake of diuretics is necessary, a loop diuretic is prescribed, rather than a thiazide series.
Instructions for use and doctors' reviews indicate that the drug is most effective for mild and moderate hypertension, when the indicators do not exceed 180 by 110 mm Hg. Art. In this case, the drug can also be used as monotherapy with limited intake of sodium compounds in the body.
Application of Captopril at high pressure, more than 180 to 110 mm Hg. Art., must be combined with the intake of diuretics. The dosage of the main medication is gradually increased until it reaches the maximum permitted concentration of 150 mg of the active ingredient per day.
We can say that the drug in question helps with any high blood pressure, especially in combination with auxiliary drugs.
Captopril is contraindicated in pregnant and lactating women.
The drug is not prescribed to patients under 18 years of age.
Before starting, as well as regularly during treatment with captopril, kidney function should be monitored.
In chronic heart failure, the drug is used subject to careful medical supervision.
With extreme caution, the drug is prescribed to patients with diffuse connective tissue diseases or systemic vasculitis; patients receiving immunosuppressive drugs, especially in the presence of impaired renal function (risk of developing serious infections that do not respond to antibiotic therapy).
In such cases, the peripheral blood picture should be monitored before using Captopril, every 2 weeks during the first 3 months of therapy and periodically in the subsequent period of treatment.
With the use of captopril and lithium salts, the content of lithium in the blood serum may increase. In combination with potassium-containing diuretics, hyperkalemia may develop.
Diuretics and vasodilators potentiate the hypotensive effect of Captopril. In combination with NSAIDs (for example, Indomethacin), Clonidine and estrogens, the hypotensive effect may decrease.
Analogs are determined by structure:
The average price of Captopril (25 mg tablets No. 20) in Moscow is 80 rubles. In Kiev, you can buy a medicine for 85 hryvnia, in Kazakhstan - for 235 tenge. Pharmacies in Minsk offer tablets No. 40 for 2-3 bel. ruble. Dispensed from pharmacies with a prescription.
Source: instrukciya-po-primeneniyu.ru
Captopril is currently available in the following several varieties:
These varieties of the drug actually differ from each other only by the presence of an additional word in the name, which reflects the abbreviation or the well-known name of the manufacturer of a particular type of drug. Otherwise, the varieties of Captopril practically do not differ from each other, since they are produced in the same dosage form, contain the same active substance, etc. Moreover, often even the active substance in the varieties of Captopril is identical, since it is purchased from large manufacturers China or India.
The differences in the names of the varieties of Captopril are due to the need for each pharmaceutical company to register the drug they produce under an original name that differs from others. And since in the past, in the Soviet period, these pharmaceutical plants produced the same Captopril using exactly the same technology, they simply add another word to the well-known name, which is an abbreviation of the name of the enterprise, and thus a unique name is obtained, from a legal point of view different from all others.
Thus, there are no significant differences between the varieties of the drug, and therefore, as a rule, they are combined under one general name "Captopril". Further in the text of the article, we will also use one name - Captopril - to refer to all its varieties.
All varieties of Captopril are available in a single dosage form - this is oral tablets. As an active substance the tablets contain a substance captopril, the name of which, in fact, gave the name to the drug.
Captopril is available in different dosages such as 6.25 mg, 12.5 mg, 25 mg, 50 mg, and 100 mg per tablet. Such a wide range of dosages allows you to choose the best option for use.
As auxiliary components Captopril varieties can contain different substances, as each plant can modify their composition, trying to achieve optimal production efficiency indicators. Therefore, to clarify the composition of the auxiliary components of each specific type of drug, it is necessary to carefully study the attached leaflet with instructions.
The prescription for Captopril in Latin is written as follows:
Rp: Tab. Cаptoprili 25 mg No. 50
D.S. Take 1/2 - 2 tablets 3 times a day.
In the first line of the prescription, after the abbreviation "Rp", the dosage form (in this case Tab. - tablets), the name of the drug (in this case - Cаptoprili) and its dosage (25 mg) are indicated. After the "No." sign, the number of tablets that the pharmacist must dispense to the prescription bearer is indicated. On the second line of the recipe after the "D.S." provides patient information with instructions on how to take the drug.
Captopril lowers blood pressure and reduces stress on the heart. Accordingly, the drug is used in the treatment of arterial hypertension, heart disease (heart failure, condition after myocardial infarction, myocardial dystrophy), as well as diabetic nephropathy.
The effect of Captopril is to suppress the activity of an enzyme that converts angiotensin I to angiotensin II, therefore the drug is classified as an ACE inhibitor (angiotensin converting enzyme). Due to the action of the drug, angiotensin II is not formed in the body - a substance that has a powerful vasoconstrictor effect and, accordingly, increases blood pressure. When angiotensin II is not produced, the blood vessels remain dilated and thus blood pressure is normal rather than elevated. Thanks to the effect of Captopril, when taken regularly, blood pressure decreases and remains within acceptable and acceptable limits. The maximum decrease in pressure occurs 1 to 1.5 hours after taking Captopril. But to achieve a stable decrease in pressure, the drug must be taken for at least several weeks (4 - 6).
Also the drug reduces stress on the heart, expanding the lumen of the vessels, as a result of which the heart muscle needs less effort to push blood into the aorta and pulmonary artery. Thus, Captopril increases the tolerance of physical and emotional stress in people with heart failure or myocardial infarction. An important property of Captopril is the absence of an effect on the value of blood pressure when used in the therapy of heart failure.
In addition, Captopril enhances renal blood flow and blood supply to the heart, as a result of which the drug is used in the complex therapy of chronic heart failure and diabetic nephropathy.
Captopril is well suited to be formulated in various combinations with other antihypertensive drugs... In addition, Captopril does not retain fluid in the body, which favorably distinguishes it from other antihypertensive drugs that have a similar property. That is why, while taking Captopril, you do not need to additionally use diuretics in order to eliminate edema caused by an antihypertensive drug.
Captopril should be taken one hour before meals, swallowing the tablet whole, without biting, chewing or otherwise crushing, but with a sufficient amount of water (at least half a glass).
The dosage of Captopril is selected individually, starting with the minimum, and gradually increasing to effective. After taking the first dose of 6.25 mg or 12.5 mg, blood pressure should be measured every half hour for three hours in order to determine the response and severity of the drug in a particular person. In the future, when the dose is increased, the pressure should also be measured regularly one hour after taking the pill.
It must be remembered that the maximum allowable daily dosage of Captopril is 300 mg. Taking the drug in an amount of more than 300 mg per day does not lead to a stronger decrease in blood pressure, but provokes a sharp increase in the severity of side effects. Therefore, taking Captopril at a dosage of more than 300 mg per day is impractical and ineffective.
Captopril for pressure(with arterial hypertension) begin to take 25 mg once a day or 12.5 mg 2 times a day. If after 2 weeks the blood pressure does not drop to acceptable values, then the dosage is increased and taken at 25-50 mg 2 times a day. If, when taking Captopril in this increased dosage, the pressure does not decrease to acceptable values, then you should additionally add Hydrochlorothiazide 25 mg per day or beta-blockers.
With moderate or mild hypertension, a sufficient dosage of Captopril is usually 25 mg 2 times a day. In severe hypertension, the dosage of Captopril is adjusted to 50-100 mg 2 times a day, doubling every two weeks. That is, in the first two weeks, a person takes 12.5 mg 2 times a day, then over the next two weeks - 25 mg 2 times a day, etc.
With high blood pressure due to kidney disease, Captopril should be taken at 6.25-12.5 mg 3 times a day. If after 1 - 2 weeks the pressure does not decrease to acceptable values, then the dosage is increased and 25 mg is taken 3-4 times a day.
With chronic heart failure Captopril should be taken at 6.25-12.5 mg 3 times a day. After two weeks, the dosage is doubled, reaching a maximum of 25 mg 3 times a day, and the drug is taken for a long time. In heart failure, Captopril is used in combination with diuretics or cardiac glycosides.
More about heart failure
With myocardial infarction Captopril can be taken on the third day after the end of the acute period. In the first 3 to 4 days, it is necessary to take 6.25 mg 2 times a day, then the dose is increased to 12.5 mg 2 times a day and drunk during the week. After that, if the drug is well tolerated, it is recommended to switch to taking 12.5 mg three times a day for 2 to 3 weeks. After this period of time, under the condition of normal tolerance of the drug, they switch to taking 25 mg 3 times a day with control of the general condition. At this dosage, Captopril is taken for a long time. If the dosage of 25 mg 3 times a day is insufficient, then it is allowed to increase it to the maximum - 50 mg 3 times a day.
More about myocardial infarction
With diabetic nephropathy It is recommended to take captopril 25 mg 3 times a day or 50 mg 2 times a day. With microalbuminuria (albumin in urine) more than 30 mg per day, the drug should be taken at 50 mg 2 times a day, and with proteinuria (protein in the urine) more than 500 mg per day, Captopril should be taken at 25 mg 3 times a day. The indicated dosages are gained gradually, starting from the minimum, and increasing twice every two weeks. The minimum dosage of Captopril for nephropathy may be different, since it is determined by the degree of impaired renal function. The minimum dosages with which to start taking Captopril for diabetic nephropathy, depending on renal function, are shown in the table.
The indicated daily dosages should be divided into 2 - 3 doses per day. Elderly people (over 65 years old), regardless of renal function, should start taking the drug at 6.25 mg 2 times a day, and after two weeks, if necessary, increase the dosage to 12.5 mg 2 to 3 times a day.
If a person suffers from any kidney disease (not diabetic nephropathy), then the dosage of Captopril for him is also determined by creatinine clearance and is the same as in diabetic nephropathy.
Captopril is contraindicated for use throughout pregnancy, since its toxic effect on the fetus has been proven in experimental animal studies. Taking the drug from the 13th to the 40th week of pregnancy can lead to fetal death or malformations.
If a woman is taking Captopril, then it should be canceled immediately, as soon as it becomes known about the onset of pregnancy.
Captopril penetrates into milk, therefore, if it is necessary to take it, you should stop breastfeeding the baby and transfer it to artificial mixtures.
For children under 18 years old, Captopril is used only if absolutely necessary, calculating the dosage individually by body weight, based on a ratio of 1 - 2 mg per 1 kg of body weight per day.
If the next pill was missed, then the next time you need to take the usual dose, not a double one.
Before starting to use Captopril, it is necessary to restore the volume of fluid and the concentration of electrolytes in the blood if they turned out to be abnormal due to taking diuretics, severe diarrhea, vomiting, etc.
During the entire period of use of Captopril, it is necessary to monitor the functioning of the kidneys. In 20% of people, while taking the drug, proteinuria (protein in the urine) may appear, which disappears on its own within 4 to 6 weeks without any treatment. However, if the concentration of protein in the urine is higher than 1000 mg per day (1 g / day), then the drug must be canceled.
Captopril should be used with caution and under close medical supervision if a person has the following conditions or diseases:
In the first three months of therapy, take a complete blood count every two weeks. Subsequently, a blood test is performed periodically, until the end of captopril. If the total number of leukocytes decreases less than 1 G / L, then the drug should be canceled. Usually, the normal number of leukocytes in the blood is restored 2 weeks after the drug is discontinued. In addition, it is necessary to determine the concentration of protein in the urine, as well as creatinine, urea, total protein and potassium in the blood during the entire period of taking Captopril every month. If the concentration of protein in the urine is higher than 1000 mg per day (1 g / day), then the drug must be canceled. If the concentration of urea or creatinine in the blood progressively increases, then the dosage of the drug should be reduced or canceled.
To reduce the risk of a sharp drop in pressure when starting to use Captopril, it is necessary to cancel diuretics 4-7 days before taking the first tablets or reduce their dosage by 2 to 3 times. If, after taking Captopril, blood pressure drops sharply, that is, hypotension develops, then you should lie on your back on a horizontal surface and raise your legs up so that they are above your head. In this position, you need to lie down for 30 - 60 minutes. If the hypotension is pronounced, then for its rapid elimination, ordinary sterile saline solution can be administered intravenously.
Since the first receptions of Captopril quite often provoke hypotension, it is recommended to select the dosage of the drug and start using it in a hospital under the constant supervision of medical personnel.
Against the background of the use of Captopril, any surgical interventions, including dental ones (for example, tooth extraction), should be performed with caution. The use of general anesthesia while taking Captopril can provoke a sharp decrease in pressure, so the anesthesiologist should be warned that a person is taking this drug.
If jaundice develops, you should immediately stop taking Captopril.
While taking the drug, a false-positive test for acetone in the urine may occur, which must be borne in mind by both the doctor and the patient himself.
It should be remembered that if the following symptoms appear while taking Captopril, you should immediately consult a doctor:
Captopril sometimes causes hyperkalemia (elevated levels of potassium in the blood). People with chronic renal failure or diabetes mellitus and those on a salt-free diet are especially at risk of hyperkalemia. Therefore, against the background of the use of Captopril, it is necessary to stop taking potassium-sparing diuretics (Veroshpiron, Spironolactone, etc.), potassium preparations (Asparkam, Panangin, etc.) and heparin.
Against the background of the use of Captopril, a person may develop a rash on the body, usually occurring in the first 4 weeks of treatment and passing with a decrease in dosage or additional intake of antihistamines (for example, Parlazin, Suprastin, Fenistil, Claritin, Erius, Telfast, etc.). Also, while taking Captopril, a persistent, unproductive cough (without sputum discharge), taste disturbance and weight loss may occur, but all these side effects disappear 2 to 3 months after the drug is stopped.
Captopril enhances the effect of hypoglycemic drugs (Metformin, Glibenclamide, Gliclazide, Miglitol, Sulfonylurea, etc.), therefore, with their combined use, the blood glucose level should be constantly monitored. In addition, Captopril enhances the effects of anesthetic drugs, pain relievers, and alcohol.
Diuretic and vasodilator drugs, antidepressants, antipsychotics, Minoxidil and Baclofen clearly enhance the hypotensive effect of Captopril, as a result of which, with their combined use, blood pressure can sharply decrease. Beta-blockers, ganglion blockers, pergolide and interleukin-3 moderately enhance the hypotensive effect of Captopril, without causing a sharp decrease in pressure.
When using Captopril in combination with nitrates (Nitroglycerin, Sodium nitroprusside, etc.), it is necessary to reduce the dosage of the latter.
Drugs of the NSAID group (Indomethacin, Aspirin, Ibuprofen, Nimesulide, Nise, Movalis, Ketanov, etc.), aluminum hydroxide, magnesium hydroxide, carbonate hydroxide, orlistat and Clonidine reduce the severity of the action of Captopril.
Captopril increases the concentration of lithium and digoxin in the blood. Accordingly, taking lithium preparations with Captopril can provoke the development of symptoms of lithium intoxication.
The simultaneous use of Captopril with immunosuppressants (Azathioprine, Cyclophosphamide, etc.), Allopurinol or Procainamide increases the risk of developing neutropenia (a decrease in the level of leukocytes in the blood below normal) and Stevens-Johnson syndrome.
The use of Captopril against the background of ongoing desensitizing therapy, as well as in combination with Estramustin and gliptins (Linagliptin, Sitagliptin, etc.) increases the risk of anaphylactic reactions.
The use of Captopril with gold preparations (Aurothiomolat, etc.) causes redness of the facial skin, nausea, vomiting and a decrease in blood pressure.
Captopril tablets can cause the following side effects from various organs and systems:
1.
Nervous system and senses:
2. Cardiovascular system and blood:
3. Respiratory system:
4. Gastrointestinal tract:
5. Urinary and reproductive systems:
6. Skin and soft tissues:
7. Allergic reactions:
8.
Other:
Captopril is contraindicated for use. if a person has the following diseases or conditions:
The above contraindications are absolute, that is, if they are present, a person should not take Captopril under any circumstances. In addition, there are relative contraindications for use, which are also called restrictions. If a person has restrictions on the use of Captopril, you can drink, but with caution, under the supervision of a physician and after a careful assessment of the risk / benefit ratio.
To relative contraindications to the use of Captopril include the following conditions or diseases:
Currently, in the domestic pharmaceutical market, Captopril has two types of analogs - these are synonyms and, in fact, analogs. Synonyms include drugs that contain the same active substance as Captopril. Analogs include drugs that contain an active substance different from Captopril, but belong to the group of ACE inhibitors and, accordingly, have a similar spectrum of therapeutic activity.
Synonyms for captopril are the following medications:
Analogues of Captopril from the group of ACE inhibitors are the following drugs:
Most of the reviews about Captopril (more than 85%) are positive, due to the high efficacy of the drug in reducing high blood pressure. The reviews indicate that the drug acts quickly and lowers pressure well, thereby normalizing health. Also, the reviews indicate that Captopril is an excellent drug for the emergency reduction of a sharply increased pressure. However, for long-term use in hypertension, Captopril is not a drug of choice, since it has a significant number of side effects that are not found in more modern drugs.
There are very few negative reviews about Captopril and they are caused, as a rule, by the development of severely tolerated side effects, which forced them to stop taking the drug.
Captopril and Enalapril are analogous drugs, that is, they belong to the same group of drugs and have a similar spectrum of action. This means that both Captopril and Enalapril lower blood pressure and improve heart health in chronic heart failure. However, there are some differences between the drugs.
Firstly, with mild to moderate hypertension, Enalapril is sufficient to take once a day, and Captopril has to be drunk 2 to 3 times a day due to the shorter duration of action. In addition, Enalapril is better at maintaining normal blood pressure with prolonged use.
Therefore, we can conclude that Enalapril is the preferred drug for long-term use in order to maintain blood pressure within acceptable values. And Captopril is more suitable for the occasional reduction of a sharp increase in blood pressure.
However, Captopril, in comparison with Enalapril, has a better effect on the heart condition in chronic heart failure, improving the quality of life, increasing the tolerance of physical and other loads, as well as preventing deaths from severe cardiac disorders. Therefore, for chronic heart failure or other heart disease, Captopril is the preferred drug.
More about Enalapril
Source: www.tiensmed.ru
Captopril is the first drug from the group of ACE inhibitors. Synthesized in 1973-75 and since that time it has been used to treat hypertension, and subsequently heart failure. The advent of captopril and other ACE inhibitors has significantly changed the approach to the treatment of diseases of the cardiovascular system.
ACE inhibitors - including captopril - have become the cornerstone of heart failure treatment. This was influenced by the impressive results of studies that evaluated the effectiveness of drugs in this class.
Important for patients! Effective treatment with captopril is only possible if you regularly take the medicine regularly, 3-4 times a day, as the doctor prescribes. This medication is well suited for the emergency treatment of a hypertensive crisis. But its main purpose is the systemic treatment of hypertension and cardiovascular diseases.
Captopril and kapoten are the same medicine. Further in the article we sometimes write "captopril" and sometimes "kapoten". It should be remembered that this is one and the same drug for hypertension and heart failure.
Only an experienced doctor can select the dosage that is suitable for you personally. An overdose of kapoten can excessively lower blood pressure and cause a heart attack. Therefore, do not self-medicate! Get tested, and then consult with a competent specialist.
This article consists of instructions for the drug captopril, which is supplemented by information from domestic and foreign medical journals. The official instructions for the use of captopril (kapoten) are written in detail, but not very clear. We have tried to present the information conveniently so that you can quickly find answers to the questions that interest you.
The instruction for the drug captopril, as well as any other materials on the Internet or in printed publications, is intended for specialists. Patients - Do not use this information for self-medication. The side effects of self-medication with pressure pills can cause irreparable harm to your health. Take capoten or captopril only as directed by your doctor. Read the section “Contraindications and precautions”.
Indications for the use of captopril:
Captopril has significant benefits in the treatment of hypertension and heart failure:
All this makes it possible to attribute captopril to the gold standard for the treatment of cardiovascular diseases.
Captopril tablets have been used to treat hypertension and heart failure since the 1970s. Millions of patients know that they are good help when you need to quickly "bring down" the pressure in a hypertensive crisis. Unfortunately, a very small part of these people take the trouble to go to the doctor, and then take the medicine for hypertension as prescribed regularly, 2-4 times a day.
Newer and more "advanced" pressure pills are considered sartans - from the group of angiotensin-II receptor blockers. These drugs appeared on the market in the late 1990s. However, large studies from 2001-2003 showed that captopril lowered blood pressure and cardiovascular mortality as well as newer, more expensive pills.
Tens of thousands of patients took part in these studies. To obtain reliable results, patients did not know which pills they were actually taking. This is called a “double-blind, placebo-controlled study”. It turned out that at the beginning of the 21st century, captopril remains an attractive option among drugs for hypertension and heart failure.
This drug works very well and, importantly, is usually cheaper than alternative drugs. Patients just do not like the fact that the pills have to be taken 3-4 times a day, and not once a day, like newer drugs.
Proven Effective and Cost-Effective Blood Pressure Supplements:
Read more about the technique in the article "Treatment of hypertension without drugs". How to order hypertension supplements from the USA - download instructions. Bring your blood pressure back to normal without the harmful side effects that chemical pills cause. Improve heart function. Become calmer, relieve anxiety, sleep like a child at night. Magnesium with vitamin B6 works wonders for hypertension. You will have excellent health, to the envy of your peers.
Captopril is recommended for the treatment of patients with congestive heart failure due to left ventricular diastolic dysfunction. The selection of the dosage should be made by a doctor, preferably in a hospital setting. Read more about this in the “How to take captopril (dosage)” section.
Kapoten significantly reduces the risk of sudden death by 20-30% for patients with heart disease or heart failure. But only on condition that it is taken for a long time and regularly, and not "from time to time." Side effects rarely necessitate discontinuation of this medication. Although sometimes severe intolerance to captopril occurs in patients.
The patient can feel an improvement in well-being no earlier than a few weeks after the start of therapy. However, this drug quickly begins to inhibit the development of heart disease, already from the first week of administration.
Also watch the video about the treatment of heart failure prepared by the friendly site Centr-Zdorovja.Com.
Captopril for pressure can be used alone, but more often it is prescribed together with other medicines for hypertension. These can be thiazide and thiazide-like diuretics, beta-blockers, calcium antagonists, or other drugs. If you want to lower your blood pressure to normal, then carefully study the article "Treatment of hypertension with combined pills."
With long-term and continuous use in patients with high blood pressure, kapoten reduces left ventricular hypertrophy of the heart, inhibits the development of heart failure. It has been proven to reduce mortality, especially in patients who have had myocardial infarction.
Most importantly, captopril protects the kidneys from damage from hypertension of any origin. It reduces proteinuria - the excretion of protein in the urine - and is a means of preventing nephrosclerosis and kidney failure. This drug does not worsen blood cholesterol levels.
According to the reviews of thousands of patients, captopril is considered one of the best means to quickly reduce blood pressure when it jumps suddenly.
The author of the review should take tests and consult a doctor in order to establish and treat the cause of his hypertension. You won't get off so easily next time. The pressure readings are very high. The risk of a sudden heart attack or stroke is significant despite feeling well.
Individual allergic reactions occur in 5-8% of people who start taking kapoten. It is necessary to agree with the doctor and switch to a drug for hypertension from another group. For example, it can be a beta blocker or angiotensin II receptor antagonist. Your doctor will decide which medication you should take based on the other symptoms you have other than high blood pressure. Do not self-medicate! As for the allergic reaction to captopril, it was impossible to predict it in advance, you should not blame the doctor. It will pass over time.
Anaprilin (propranolol) is an outdated drug that, although it lowers blood pressure, does not reduce, but even increases mortality. Your doctor is a dense man, does not follow the news at all. I strongly recommend that you contact another specialist. And, of course, try our method of treating hypertension without drugs.
This is probably the most that can be done in your situation. Treatment of hypertension in older people is complicated by their monstrous stubbornness. If an older person can be persuaded to take pills regularly, that's good. It is almost impossible to drive to a polyclinic to be examined, get tested, normalize food and move more. But retirement years can be one of the happiest times in life. Today's old people just don't know what they are missing. I hope that at their age we will live differently, more fully.
If a patient is diagnosed with renovascular or renoparenchymal hypertension, then he or she has a serious kidney problem that causes hypertension. Although in most cases it is the other way around - first, hypertension damages the kidneys, and then a vicious circle forms.
In the case of renovascular (problems with the vessels of the kidneys) or renoparenchymal (problems with the filtering elements of the kidneys) hypertension - treatment with captopril begins with lower doses. Then the dosage is carefully adjusted according to the results of the blood test for creatinine. It is also desirable to monitor serum potassium levels.
The official instruction for the drug captopril for chronic heart failure recommends starting with a dosage of 6.25 mg 2-3 times a day. Then this dosage can be gradually increased, with an interval of at least 2 weeks.
After taking the first dose of 6.25 mg, it is recommended to measure the patient's blood pressure every 30 minutes during the first 3 hours to assess the effect of the drug. The average maintenance dose of captopril for “cores” is 25 mg 2-3 times a day.
With hypertension, the instruction recommends starting to take kapoten with a dosage of 25 mg 2 times a day. The second option is 12.5 mg 3 times a day. The dosage of the tablets is specified according to the results of blood pressure monitoring, at home and in the hospital.
The maximum dosage of captopril for hypertension is 50 mg 3 times a day. Increasing the dose beyond this does not further lower blood pressure, but dramatically increases the likelihood of side effects. We remind you that captopril for pressure is usually used as part of a combination therapy. Read more in the article "Treatment of Hypertension with Combined Drugs"
For elderly patients, the initial dosage of captopril is 6.25 mg 2 times a day. If possible, it is desirable to maintain it at this level. The article "What medicines for hypertension are prescribed for elderly patients" may also be useful for you.
With moderate renal impairment (glomerular filtration rate of 30 ml / min / 1.73 m2), patients can take captopril up to 75-100 mg per day. If kidney disease is more pronounced (glomerular filtration rate less than 30 ml / min / 1.73 m2), then start with a dosage of 6.25 mg 2-3 times a day. And then they try to increase it carefully, controlling the test results. If diuretics are also required, then not thiazide diuretics are prescribed, but loop diuretics.
Angiotensin II is a hormone that causes blood vessels to constrict and also increases sodium retention in the body. It is formed from angiotensin-I by an angiotensin-converting enzyme. Captopril belongs to drugs from the group of ACE inhibitors. This means that it inhibits the activity of the angiotensin-converting enzyme, decreasing the concentration of angiotensin-II in the blood.
As a result, the total peripheral vascular resistance decreases, the cardiac output and exercise tolerance increase. Kapoten tablets increase blood flow in the vessels that feed the heart and kidneys. With prolonged use, it reduces the severity of hypertrophy of the myocardium and blood vessel walls.
How captopril lowers blood pressure:
How this medicine protects the heart:
Protection of blood vessels from damage in diabetes mellitus:
After oral administration, captopril is rapidly absorbed, begins to act in 15-60 minutes, and the peak concentration in the blood is reached within an hour. Eating food together with the drug reduces its content in the blood to 30-40%, therefore kapoten tablets should be prescribed 1 hour before meals or 1-1.5 hours after meals.
The duration of the effect on lowering blood pressure depends on the dose and frequency of administration. It takes several weeks for the full pharmacological effect to develop.
Contraindications to the appointment of captopril:
In patients with autoimmune diseases, including systemic lupus erythematosus, the level of leukocytes in the blood in the first 3 months of therapy with captopril should be monitored every 2 weeks, and then once every 2 months. If this level decreases by 2 times from the initial one, then the drug must be canceled.
Special instructions for patients during therapy with captopril or kapoten:
From the side of the cardiovascular system: excessive lowering of blood pressure, tachycardia (increased heart rate), swelling of the legs.
Orthostatic hypotension is a sharp drop in blood pressure when the patient rises from a lying or sitting position. Manifested by dizziness, or even fainting.
From the urinary system: proteinuria (excretion of protein in the urine), the development of renal dysfunction - an increase in the level of urea and creatinine in the blood.
From the hematopoietic system (very rare):
From the side of the central nervous system: dizziness, headache, ataxia (disorder of coordination of movements), disorders of limb sensitivity, drowsiness, blurred vision, feeling of chronic fatigue.
On the part of the respiratory system: dry cough that passes after discontinuation of the drug, and also very rarely bronchospasm and pulmonary edema.
Dermatological reactions: rash, itchy skin, increased sensitivity to light.
From the gastrointestinal tract, liver, pancreas: taste disturbances, dry mouth, inflammation of the oral mucosa, nausea, poor appetite, rarely - diarrhea, abdominal pain, increased activity of hepatic transaminases (enzymes), increased bilirubin, hepatitis ...
If you take captopril concurrently with potassium-sparing diuretics or potassium preparations, this can lead to hyperkalemia - an increased level of potassium in the blood.
With the simultaneous administration of lithium salts, the concentration of lithium in the blood serum may increase.
If you take kapoten at the same time as allopurinol or procainamide, it increases the likelihood of developing neutropenia and / or Stevens-Johnson syndrome.
The use of this drug in patients receiving immunosuppressive therapy (for example, cyclophosfacin or azathioprine) increases the risk of developing hematological disorders (diseases of the blood system).
With the simultaneous use of ACE inhibitors and gold preparations (sodium aurothiomalate), a complex of symptoms has been described, which included facial flushing, nausea, vomiting and a decrease in blood pressure.
Concomitant use of insulin or diabetes pills that lower blood sugar increases the risk of hypoglycemia.
The following drugs reduce or slow down the blood pressure lowering effect of captopril:
The effectiveness of captopril in lowering blood pressure is enhanced by diuretics, as well as vasodilators - drugs that relax and dilate blood vessels.
In 2009-2010, on the basis of the regional clinical hospital of the Ukrainian city of Rivne, a study was conducted on the frequency of adverse reactions from taking captopril. The study involved patients with mild to moderate arterial hypertension. These were 500 people who were treated in a hospital, and another 499 patients who took kapoten on an outpatient basis, that is, at home.
What daily doses did these patients receive:
Some of them received monotherapy with captopril, and the rest - as part of a combination of drugs for hypertension.
Distribution of patients by type of treatment with pressure pills (monotherapy or combined):
Of the 500 patients who were treated in the hospital, side effects from captopril treatment were found in only 5 people (1%):
All these are not serious side effects that quickly disappeared after the drug was discontinued. They did not require additional costs for treatment and did not increase the time patients spent in the hospital.
Of the 499 patients who took captopril for blood pressure on an outpatient basis, according to the results of the questionnaire, 72 people (14%) complained about side effects. The list of side effects included:
Of these 72 people, 52 patients canceled the drug, and 20 continued to take it despite the side effects because they thought it had more health benefits.
It was found that the risk of side effects of kapoten is significantly increased in patients over the age of 70. And the more “experience” of hypertension the patient has, the higher the likelihood of side effects of the drug. At the same time, the authors of the study were unable to trace the relationship between the dosage of tablets and pressure and the frequency of adverse reactions.
Noteworthy is the high level of side effects in patients who took captopril on an outpatient basis. The study authors explained this as follows. 13.8% of these patients additionally took adelfan, and another 16.01% - clonidine. And these are only those who confessed to the doctor at the reception ... This situation is explained by the low culture of patients, their tendency to self-medicate and unwillingness to spend money on more expensive high-quality drugs for hypertension. It is worth emphasizing that none of the 999 people who were treated for high blood pressure with a hood had severe side effects.
Captopril release form - tablets of 25 and 50 mg. They are packaged in contour cells of 10 pcs. A cardboard box can contain from 1 to 10 contour cells, i.e. from 10 to 100 capoten tablets.
See also the article “ ACE inhibitors: side effects“.
Captopril STI, the instructions for use of which include this drug in the group of angiotensin-converting enzyme inhibitors, is considered a popular remedy for high blood pressure.
Angiotensin-I in the blood under the influence of various factors is converted into angiotensin-II, which has a pronounced vasoconstrictor effect, as a result of which the blood pressure rises. An ACE inhibitor slows down this process, allowing the pressure to be normal for a longer time.
People suffering from various diseases of the heart and cardiovascular system, as well as those at risk - exposed to severe stress, nervous, psycho-emotional and physical stress, can drink with the recommendation of a doctor and according to the instructions. The main indications for the use of Captopril STI in the instructions are as follows: 
Important! The maximum possible dose of the substance per day according to the instructions for use is 150 mg, above which the drug cannot be drunk due to the onset of the risk of side effects.
The medicine can be taken in two ways - as a regular therapy every day according to the prescriptions of the attending physician, as well as to stop sudden spikes in blood pressure of more than 15%.
Some people take Captopril STI under the tongue during a sudden increase in blood pressure. In the official instructions there is no recommendation for sublingual administration, and patients who take the drug in this way often complain of irritation of the oral mucosa and the appearance of ulcers like stomatitis.
If, with the regular use of Captopril STI, according to the instructions, there is no decrease in blood pressure, you should seek the advice of a therapist or cardiologist. It is possible that there is a more serious disturbance in the work of the heart and blood vessels.
In some cases, there is an individual immunity of the body to the components of the drug, and it just needs to be replaced with an analogue (for example, Dapril, Lizacard and others).
It is forbidden to take caffeine-containing preparations (Citramon, Kaffetin). It is better to limit the intake of alcohol during hypertension as much as possible or completely exclude it, since it gives a short-term expansion of the walls of blood vessels, which then spasm. You should also limit or completely exclude the use of coffee and strong tea, since these products contribute to an increase in blood pressure.
For more information on hypertension, see this video:
Captopril-STI is prescribed mainly for high blood pressure. The mechanism of action of the drug is the expansion of large blood vessels, which contributes to the normalization of blood pressure.
You can take the remedy only as directed by a doctor in order to avoid undesirable reactions, especially if a person is susceptible to various types of allergies.
Captopril is the name of the active ingredient of the drug.
C09AA01 - anatomical-therapeutic-chemical classification code.
The product is produced in tablet form. Tablets with a dosage of 50 mg of captopril are packaged in cell packs of 10 pcs. in each of them.
The drug is not produced in capsules.
The medication is among the antihypertensive drugs (ACE blocker).
There are a number of such medicinal properties of high pressure pills:
After oral administration of the drug, more than half of it is absorbed from the digestive tract.
It is advisable to use the tablets before or after a meal, since if you perform these actions at the same time, then the absorption process of the active ingredient slows down by 30%.
The maximum concentration of captopril in blood plasma is observed within an hour. Metabolism is carried out in the liver. Decay products are excreted in large volumes by the kidneys.
With renal dysfunction, an accumulation of a biologically active substance in the body is observed.
The tool is effective in a number of such cases:
The main contraindication is organic intolerance to the active component of the drug. Aortic stenosis is also included in the list of restrictions.
The maximum daily dose should not exceed 0.15 g of the active substance, because there is a high risk of developing arterial hypotension.
Apply 75 mg per day. You will need at least 2 doses during the day.
You should start taking with 6.25-12.5 mg three times a day. After 2 weeks, the dosage is doubled by taking orally up to 0.025 g of active ingredient 3 times a day for a long time period.
It is important to use diuretics during treatment with an ACE inhibitor.
An hour before a meal, take 12.5 mg of the drug twice a day. If there is a good tolerance of the dose taken within an hour, then treatment can be continued.
The exact dosage, frequency and time interval for taking the drug is established by the doctor. The medical specialist takes into account the severity of the pathological process and the individual characteristics of the body.
It is important to study the instructions before starting therapy in order to avoid negative consequences.
The positive dynamics of clinical symptoms has been observed for an hour.
The frequency of admission should not exceed 3 times a day.
The medicine can provoke a number of undesirable reactions.
Stool disorder is possible, as well as nausea during prolonged therapy. Decreased appetite is common in patients with chronic bacterial imbalance.
Side effects are rare.
Patients often complain of headache, muscle weakness and sensations of numbness, tingling sensations, and crawling creeps.
The concentration of urea and creatinine in the blood increases against the background of renal failure.
Cases of dry cough are not uncommon.
With increased sensitivity to the active substance, a rash occurs.
Deviations from the norm are rarely observed.
Angioedema is rarely observed.
Driving should be avoided during drug treatment.
It is worth considering a number of features during treatment with a remedy.
It is forbidden to take pills in any trimester and while breastfeeding.
It is important to consider the following:
Sale of tablets is allowed without a doctor's prescription.
The cost of the funds is about 60 rubles.
It is important to limit the access of children to the medicine.
The tablets can be used within 3 years from the date of production.
